常见吲哚合成反应汇总

By condensation of azidoacetates with aromatic aldehydes, 2-azido-3-aryl acrylates can be obtained. They are heated and cyclized to form indole-2-carboxylate derivatives. Generally, only electron rich aromatic rings (benzene ring with push electrons, furan, thiophene, pyrrole) can be cyclized using this method. details